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Zika Virus and Birth Defects - Reviewing the Evidence for Causality

Rasmussen, S., Jamieson, D., Honein, M., and Petersen, L. (2016). Zika Virus and Birth Defects - Reviewing the Evidence for Causality. The New England Journal of Medicine. 374:1981-1987.

The authors evaluated available data to determine causality of Zika infection and birth defects, most notably microcephaly. This evidence included Zika virus infection during specific times in pregnancy, a specific rare phenotype involving microcephaly, and data that support biologic plausibility. The researchers concluded that the evidence supports a causal relationship between Zika virus infection and birth defects.
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