Neurodevelopmental Abnormalities in Children with In Utero Zika Virus Exposure Without Congenital Zika Syndrome
Mulkey, S., Arroyave-Wessel, M., Peyton, C., et al. (2020). Neurodevelopmental Abnormalities in Children with In Utero Zika Virus Exposure Without Congenital Zika Syndrome. JAMA Pediatrics. 174(3): 269-276.
The authors of this cohort study investigate infants exposed to Zika virus (ZIKV) in utero with no clinical sign of Congenital Zika Syndrome (CZS). A longitudinal study of infant neurodevelopment includes infants born to women who met the Centers for Disease Control and Prevention criteria for probable Zika virus infection and laboratory confirmed tests during their pregnancies. The focus is to evaluate the early neurodevelopmental outcomes of infants with normocephaly who were exposed to the virus and had normal neuroimaging findings at birth and whether they are at risk as they age for neurodevelopmental delays.