Systemic Bioavailability of Sublingual Atropine Ophthalmic Solution a Phase I Study in Healthy Volunteers with Implications for Use as a Contingency

The authors conducted a phase I study to understand whether atropine administered under the tongue could be a successful medical countermeasure against organophosphorus nerve agent and organophosphate pesticide toxicity. They found that sublingual atropine may be an effective countermeasure for this nerve agent.