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Resuscitation with Blood Products in Patients with Trauma-Related Haemorrhagic Shock Receiving Prehospital Care

Crombie, N., Doughty, H., Bishop, J., et al. (2022). Resuscitation with Blood Products in Patients with Trauma-Related Haemorrhagic Shock Receiving Prehospital Care (Rephill): A Multicentre, Open-Label, Randomised, Controlled, Phase 3 Trial. Lancet Haematology. 9(4):e250-e261.
The authors conducted a randomized control trial to compare prehospital packed red blood cells and lyophilized plasma (PRBC-LyoPlas) to 0.9% sodium chloride to improve perfusion and reduce mortality after traumatic hemorrhage. The trial did not demonstrate that PRBC-LyoPlas was superior to sodium chloride in the prehospital setting. The authors recommend further research on transfusion protocols and careful consideration before implementing prehospital transfusion programs.
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