Wester, A. and Shetty, A. (2016). Peramivir Injection in the Treatment of Acute Influenza: A Review of the Literature. Infection and Drug Resistance. 9:201-214.
The authors review the literature on the use of peramivir for acute influenza treatment. They found that it is effective against a variety of influenza A and B subtypes and that its injectable form may be favorable for treating critically ill, hospitalized patients. While they found positive results in observational studies in pregnant women, pediatric patients, patients receiving continuous renal replacement therapy, and patients undergoing extracorporeal membrane oxygenation, there is a lack of clinical trials demonstrating the efficacy of peramivir in these populations.