Stinger, H., Spinella, P., Perkins, J., et al. (2008). The Ratio of Fibrinogen to Red Cells Transfused Affects Survival in Casualties Receiving Massive Transfusions at an Army Combat Support Hospital. (Abstract only.) The Journal of Trauma. 64(2 Suppl): S79-85.
The authors sought to determine whether increased ratios of fibrinogen (a soluble protein present in blood plasma) to red blood cells (RBCs) decreased mortality in combat casualties requiring massive transfusion. They found that “the transfusion of an increased fibrinogen: RBC ratio was independently associated with improved survival to hospital discharge, primarily by decreasing death from hemorrhage.”