Holcomb, J., Tilley, B., Baraniuk, S., et al. (2015). Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients with Severe Trauma: The PROPPR Randomized Clinical Trial. (Abstract only.) Journal of the American Medical Association. 313(5): 471-482.
The authors sought to evaluate the safety and effectiveness of transfusing patients with major bleeding (as a result of severe trauma) using a different ratio of plasma, platelets, and red blood cells. No significant differences were detected in mortality at 24 hours or at 30 days.