Transfusion of Plasma Platelets and Red Blood Cells in a 111 vs a 112 Ratio and Mortality in Patients with Severe Trauma The PROPPR Randomized

Holcomb, J., Tilley, B., Baraniuk, S., et al. (2015). Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients with Severe Trauma: The PROPPR Randomized Clinical Trial. (Abstract only.) Journal of the American Medical Association. 313(5): 471-482.
The authors sought to evaluate the safety and effectiveness of transfusing patients with major bleeding (as a result of severe trauma) using a different ratio of plasma, platelets, and red blood cells. No significant differences were detected in mortality at 24 hours or at 30 days. This classic article may provide guidance though there is some variance in individual health care facility protocol.
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