Three Mutations Switch H7N9 Influenza to Human-Type Receptor Specificity

de Vries, R., Peng, W., Grant, O., et al. (2017). Three Mutations Switch H7N9 Influenza to Human-Type Receptor Specificity. PLOS Pathogens. 13(6):e1006390.
The authors conducted mutation analyses to determine whether H7N9 is capable of acquiring human-type receptor specificity, which could enable effective transmission of the virus from human to human. They found that three amino acid mutations were needed to change specificity to human-type receptors.
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