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Long-Term Persistance of the Pathophysiologic Response to Severe Burn Injury

Jeschke, M.G., Gauglitz, G.G., Kulp, G.A., et al. (2012). Long-Term Persistance of the Pathophysiologic Response to Severe Burn Injury. PLoS One. 6(7):e21245.

This cohort study was conducted from 1998-2008, and enrolled 997 pediatric burn patients and a matched control group to measure hypermetabolic and inflammatory changes for 36 months post-burn. The authors found that alterations persisted for far longer than originally thought, and that severely burned pediatric patients require treatment for a longer period of time.
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