Jeschke, M.G., Gauglitz, G.G., Kulp, G.A., et al. (2012). Long-Term Persistance of the Pathophysiologic Response to Severe Burn Injury. PLoS One. 6(7):e21245.
This cohort study was conducted from 1998-2008, and enrolled 997 pediatric burn patients and a matched control group to measure hypermetabolic and inflammatory changes for 36 months post-burn. The authors found that alterations persisted for far longer than originally thought, and that severely burned pediatric patients require treatment for a longer period of time.