Jeschke, M.G., Kulp, G.A., Kraft, R., et al. (2010). Intensive Insulin Therapy in Severely Burned Pediatric Patients: A Prospective Randomized Trial. American Journal of Respiratory and Critical Care Medicine. 182(3):351-9.
This prospective randomized study of 239 severely burned pediatric patients with burns over greater than 30% of their bodies showed that intensive insulin therapy decreased mortality in the treatment group vs. the control group. Insulin was shown to improve organ function, and to decrease catabolism, insulin resistance, sepsis, and infection.