Evaluation of Prolonged Versus Continuous Infusions of PiperacillinTazobactam During Shortages of Small Volume Parenteral Solutions

This retrospective cohort study compared outcomes of patients receiving prolonged infusions of piperacillin/tazobactam to those receiving continuous infusions in a single center during a national shortage of small volume solutions. The authors found no differences in mortality, length of therapy, incidences of thrombocytopenia, acute renal failure, seizures, or 30-day readmission rates.