Clinical Guidance for Smallpox Vaccine Use in a Postevent Vaccination Program

This report provides recommendations for the clinical use of the three smallpox vaccines included in the Strategic National Stockpile for persons exposed to the virus or at high risk for infection during a post-event vaccination program. Descriptions, administration and dosage, regulatory status, efficacy, and safety information are included for each vaccine. The report also includes recommendations on use, including considerations for contraindications and special populations, and identifies remaining knowledge gaps and areas for future research.